Antibodies to adalimumab are associated with future inflammation in Crohn's patients receiving maintenance adalimumab therapy: a post hoc analysis of the Karmiris trial.
Filip BaertVenkateswarlu KondraguntaSteven LocktonNiels Vande CasteeleScott HauensteinSharat SinghKonstantinos KarmirisMarc FerranteAnn GilsSéverine VermeirePublished in: Gut (2015)
ATA were detected in 20% of patients. Risk of ATA formation increased with lower early serum ADL concentration and in patients not on IMM. ATA and ADL were strongly associated with higher future CRP level and discontinuation of ADL.