A novel inhibitory peptide of Dll4-Notch1 signaling and its proangiogenic functions.

We developed TAT-ANK peptide, a new inhibitor of Notch signaling. This peptide will be of significant interest to the scientists studying Dll4-Notch1 signaling as well as to clinicians who perform clinical trials using Notch signaling inhibitors. Furthermore, our findings will have important conceptual and therapeutic implications on angiogenesis related diseases.