Essential role of aerobic glycolysis in epithelial-to-mesenchymal transition during carcinogenesis.
Chandra Prakash PrasadAjay GogiaAtul BatraPublished in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2022)
Epithelial-to-mesenchymal transition (EMT) confers the most lethal characteristics to cancer cells i.e., metastasis and resistance to chemo-and-radio-therapy, and therefore exhibit an appealing target in the field of oncology. Research in the past decade has demonstrated the crucial role of aerobic glycolysis in EMT, which is generally credited as the glucose metabolism for the creation of biomass such as fatty acids, amino acids, and nucleotides thereby providing building blocks for limitless proliferation. In the present review, apart from discussing EMT's evident role in the metastatic process and cancer stemness, we also talked about the vital role of glycolytic enzymes viz. GLUTs, HKs, PGI, PFK-1, aldolase, enolase, PK, LDHA, etc. in the induction of the EMT process in cancerous cells.
Keyphrases
- epithelial mesenchymal transition
- signaling pathway
- induced apoptosis
- fatty acid
- squamous cell carcinoma
- amino acid
- stem cells
- palliative care
- papillary thyroid
- cell cycle arrest
- photodynamic therapy
- wastewater treatment
- locally advanced
- squamous cell
- cell death
- mesenchymal stem cells
- combination therapy
- bone marrow
- drug delivery