Hypersensitivity reactions to proton pump inhibitors in childhood.

Francesca Mori Fabrizio Franceschini Francesca Saretta Annamaria BianchiPaolo BottauSilvia CaimmiGiuseppe CrisafulliLucia LiottiClaudia PaglialungaCarlo Caffarelli

Published in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2021)

Hypersensitivity reactions (HRs) to proton pump inhibitors (PPIs) are mainly described in adults. Anyway, increased use of PPIs in childhood has been observed in recent years. In the literature, only case reports are published on children. Most of the PPI HRs are IgE-mediated. Skin test concentrations and allergy workup protocols used for adults are also applied in children. This study underlies that multicentric pediatric studies focusing on PPI reactions in children are needed.

Keyphrases

young adults
systematic review
childhood cancer
randomized controlled trial
drug induced
protein protein
early life
small molecule
atopic dermatitis