Computer-Aided Imaging Analysis of Probe-Based Confocal Laser Endomicroscopy With Molecular Labeling and Gene Expression Identifies Markers of Response to Biological Therapy in IBD Patients: The Endo-Omics Study.
Marietta IacucciLouisa JefferyAnimesh AcharjeeEnrico GrisanAndrea BudaOlga Maria NardoneSamuel C L SmithNunzia LabarileDavide ZardoBella UngarStuart HunterRen MaoRosanna CannatelliUday N ShivajiTommaso Lorenzo ParigiGary M ReynoldsGeorgios V GkoutosSubrata GhoshPublished in: Inflammatory bowel diseases (2022)
Higher mucosal binding of the drug target is associated with response to therapy in UC. In vivo, mucosal and microvascular changes detected by pCLE are associated with response to biologics in inflammatory bowel disease. Anti-TNF-responsive UC patients have a less inflamed and fibrotic state pretreatment. Chemotactic pathways involving CXCL6 or CXCL13 may be novel targets for therapy in nonresponders.
Keyphrases
- end stage renal disease
- gene expression
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- emergency department
- dna methylation
- genome wide
- quantum dots
- stem cells
- systemic sclerosis
- cancer therapy
- drug delivery
- ulcerative colitis
- optical coherence tomography
- single molecule
- idiopathic pulmonary fibrosis
- binding protein