Effect of Universal Testing and Treatment on HIV Incidence - HPTN 071 (PopART).
Richard J HayesDeborah DonnellSian FloydNomtha MandlaJustin BwalyaKalpana SabapathyBlia YangMwelwa PhiriAb SchaapSusan H EshlemanEstelle Piwowar-ManningBarry KosloffAnelet JamesTimothy SkallandEthan WilsonLynda EmelDavid MacleodRory DunbarMusonda SimwingaNozizwe MakolaVirginia BondGraeme HoddinottAyana MooreSam GriffithNirupama Deshmane SistaSten H VermundWafaa El-SadrDavid N BurnsJames R HargreavesKatharina HauckChristophe FraserKwame ShanaubePeter BockNulda BeyersHelen AylesSarah Fidlernull nullPublished in: The New England journal of medicine (2019)
A combination prevention intervention with ART provided according to local guidelines resulted in a 30% lower incidence of HIV infection than standard care. The lack of effect with universal ART was unanticipated and not consistent with the data on viral suppression. In this trial setting, universal testing and treatment reduced the population-level incidence of HIV infection. (Funded by the National Institute of Allergy and Infectious Diseases and others; HPTN 071 [PopArt] ClinicalTrials.gov number, NCT01900977.).
Keyphrases
- antiretroviral therapy
- hiv infected
- infectious diseases
- risk factors
- randomized controlled trial
- human immunodeficiency virus
- hiv positive
- healthcare
- hiv aids
- quality improvement
- palliative care
- clinical trial
- hepatitis c virus
- study protocol
- combination therapy
- electronic health record
- pain management
- clinical practice
- open label
- south africa
- health insurance