ERG assessment of altered retinal function in canine models of retinitis pigmentosa and monitoring of response to translatable gene augmentation therapy.

Nathaniel Pasmanter Laurence M Occelli Simon M Petersen-Jones

Published in: Documenta ophthalmologica. Advances in ophthalmology (2021)

Modeling of rod and cone a-waves and the luminance-response function of the scotopic b-wave characterized the loss of rod photoreceptor function in two dog models of retinitis pigmentosa and showed the effectiveness of gene augmentation therapy in restoring normal functional parameters.

Keyphrases

genome wide
randomized controlled trial
systematic review
optical coherence tomography
gene expression
dna methylation
mesenchymal stem cells
cell therapy
transcription factor