Adenosine kinase inhibits β-cell proliferation by upregulating DNA methyltransferase 3A expression.

Ting ChenJiayu YuXin GuoSiqi WangZhihua WangYang ChenXiang HuHuiqing LiMingxing Xie Juan Zheng

Published in: Diabetes, obesity & metabolism (2024)

In this study, we found that the overexpression of ADK decreased the expression of several genes that regulate β cells, resulting in the inhibition of β-cell proliferation and dysfunction by upregulating the expression of DNMT3A.

Keyphrases

cell proliferation
poor prognosis
binding protein
dna methylation
induced apoptosis
cell cycle
long non coding rna
oxidative stress
genome wide
gene expression
cell cycle arrest
signaling pathway
pi k akt
cell death
transcription factor