Intake of mother's milk by very-low-birth-weight infants and variation in DNA methylation of genes involved in neurodevelopment at 5.5 years of age.
Jingxiong XuJean ShinMeghan McGeeSharon UngerNicole BandoJulie SatoMarlee M VandewouwYash PatelHelen M BransonTomáš PausZdenka PausovaDeborah L O'ConnorPublished in: The American journal of clinical nutrition (2022)
In-hospital percentage mother's milk intake by VLBW infants was associated with variations in DNAm of neurodevelopmental genes at 5.5 y; some of these DNAm variations are associated with brain structure and IQ.This trial was registered at isrctn.com as ISRCTN35317141 and at clinicaltrials.gov as NCT02759809.
Keyphrases
- low birth weight
- dna methylation
- preterm infants
- human milk
- genome wide
- preterm birth
- nk cells
- weight gain
- healthcare
- study protocol
- white matter
- resting state
- clinical trial
- gene expression
- phase iii
- phase ii
- functional connectivity
- randomized controlled trial
- copy number
- emergency department
- body mass index
- physical activity
- open label