NFAT5-mediated CACNA1C expression is critical for cardiac electrophysiological development and maturation.

Wei LiNai-Zhong ZhengQi YuanKe XuFan YangLei GuGu-Yan ZhengGuo-Jie LuoChun FanGuang-Ju JiBo ZhangHuiqing CaoXiao-Li Tian

Published in: Journal of molecular medicine (Berlin, Germany) (2016)

Nfat5 binds to a consensus sequence TGGAAGCGTTC in the promoter of Cacna1c. Nfat5 activates the transcription of Cacna1c. Nfat5 knockdown suppresses Cacna1c expression, decreases L-type calcium current, and results in non-beating ventricle. NFAT5-mediated expression of CACNA1C is evolutionarily conserved. NFAT5-mediated CACNA1C expression is critical for cardiac electrophysiological development and maturation.

Keyphrases

poor prognosis
nuclear factor
transcription factor
binding protein
left ventricular
gene expression
dna methylation
long non coding rna
coronary artery