Hybrid human-porcine factor VIII proteins partially escape the inhibitory effects of anti-factor VIII inhibitor alloantibodies having A2 or C2 domain specificity.
Kuniyoshi MizumachiYuto NakajimaNaruto ShimonishiShoko FurukawaKenichi OgiwaraMasahiro TakeyamaKeiji NogamiPublished in: Haemophilia : the official journal of the World Federation of Hemophilia (2023)
Hybrid FVIII proteins containing porcine FVIII A2 and/or C2 domain(s) could support effective therapy in PwHA-I by avoiding neutralization.