WEE1 Dependency and Pejorative Prognostic Value in Triple-Negative Breast Cancer.

Alexandre de NonnevillePascal FinettiDaniel BirnbaumEmilie MamessierFrançois Bertucci

Published in: Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2021)

The WEE1 G2 checkpoint kinase acts as a negative cell cycle regulator for entry into mitosis (G2-to-M transition). This comment extends a recent Advanced Science paper by reporting higher WEE1-dependency of triple negative breast cancer (TNBC) cell lines, pejorative prognostic value of WEE1 expression in TNBC clinical samples as well as higher expression of biomarkers of sensitivity to WEE1 inhibitor.

Keyphrases

cell cycle
poor prognosis
cell proliferation
public health
dna damage
binding protein
emergency department
long non coding rna
oxidative stress
protein kinase