Circulating tumor cells PD-L1 expression detection and correlation of therapeutic efficacy of immune checkpoint inhibition in advanced non-small-cell lung cancer.
Qing ZhouXiangning LiuJi LiBing TongYan XuMin-Jiang ChenXiaoyan LiuXiaoxing GaoYuequan ShiJing ZhaoWei ZhongMengzhao WangPublished in: Thoracic cancer (2023)
CTCs and tumor tissues reveal heterogeneous expression of PD-L1 in NSCLC patients. Patients with baseline PD-L1 expression on CTCs or tissue showed prolonged mPFS and may help to identify the subsets of patients who potentially benefit from immunotherapy.
Keyphrases
- circulating tumor cells
- advanced non small cell lung cancer
- end stage renal disease
- epidermal growth factor receptor
- circulating tumor
- small cell lung cancer
- ejection fraction
- poor prognosis
- newly diagnosed
- chronic kidney disease
- gene expression
- genome wide
- prognostic factors
- dna methylation
- long non coding rna
- patient reported outcomes
- single cell
- label free