Matrix Metalloproteinase-1 (MMP1) Upregulation through Promoter Hypomethylation Enhances Tamoxifen Resistance in Breast Cancer.

Hyeon Woo KimJae Eun ParkMinjae BaekHeejoo KimHwee Won JiSung Hwan YunDawoon JeongJuyeon HamSungbin ParkXinpei LuHan-Sung KangSun Jung Kim

Published in: Cancers (2022)

MMP1 can be upregulated through promoter hypomethylation in tamR breast cancer, functioning as a resistance driver gene. MMP1 can be a potential target to suppress tamR to achieve better prognoses of breast cancer patients.

Keyphrases

dna methylation
cell migration
transcription factor
gene expression
genome wide
poor prognosis
cell proliferation
copy number
risk assessment
human health
young adults