Physical activity, low-grade inflammation, and psychological responses to the COVID-19 pandemic among older adults in England.

Mental health responses to the COVID-19 pandemic have been widely studied, but less is known about the potentially protective role of physical activity (PA) and the impact of low-grade inflammation. Using a sample of older adults from England, this study tested (1) if pre-pandemic PA and its changes during the pandemic were associated with mental health responses; (2) if older adults with low-grade inflammation experienced greater increases in depression and anxiety, compared to pre-pandemic levels; (3) if PA attenuated the association between inflammation and depression/anxiety. The study used data from the English Longitudinal Study of Ageing, a cohort study following a national sample aged 50+. Information on mental health and PA were collected before the pandemic (2016/17 and 2018/19) and during November and December 2020. Inflammation was ascertained using pre-pandemic C-reactive protein (CRP). Analyses were adjusted for sociodemographic and health-related factors and pre-pandemic mental health. Increasing PA from before to during the pandemic was linked to reduced odds of depression ( OR = 0.955, 95% CI [0.937, 0.974]) and anxiety ( OR = 0.954, 95% CI [0.927; 0.982]). Higher pre-pandemic PA was associated with reduced odds of depression ( OR = 0.964, 95% CI [0.948, 0.981]) and anxiety ( OR = 0.976, 95% CI [0.953, 1.000]), whereas elevated CRP was associated with 1.343 times higher odds of depression (95% CI [1.100, 1.641]). PA did not attenuate the inflammation-depression association. The findings suggest that PA may contribute to psychological resilience among older adults, independently of inflammation. Further research is needed to explore the psychobiological pathways underlying this protective mechanism.