Measuring Circulating Complement Activation Products in Myeloperoxidase- and Proteinase 3-Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
Eveline Y WuElizabeth A McInnisSonia Boyer-SuavetCarmen E MendozaLydia T AybarKristin B KennedyCaroline J PoultonCandace D HendersonYichun HuSusan L HoganPeiqi HuHong XiaoPatrick H NachmanJ Charles JennetteRonald J FalkDonna O BunchPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2019)
Complement activation occurs in both MPO-positive AAV and PR3-positive AAV. The complement activation profile differs according to disease activity and possibly ANCA serotype. Futhan reduces in vitro complement activation and provides a more accurate measurement.