Contribution of Lipoprotein(a) to Polygenic Risk Prediction of Coronary Artery Disease: A Prospective UK Biobank Analysis.

Hasanga D Manikpurage Audrey Paulin Arnaud GirardAida EslamiPatrick Mathieu Sébastien Thériault Benoit J Arsenault

Published in: Circulation. Genomic and precision medicine (2023)

Compared with individuals with a low genetic risk of CAD (low CAD-PRS and low Lp[a] levels), those with a high genetic risk (high CAD-PRS and high Lp[a] levels) had a 5-fold higher CAD risk. These results highlight a substantial contribution of genetic risk factors to CAD and that accurate estimation of genetic risk of CAD may need to consider blood levels of Lp(a).

Keyphrases

coronary artery disease
percutaneous coronary intervention
cardiovascular events
genome wide
coronary artery bypass grafting
risk factors
copy number
type diabetes
heart failure
cardiovascular disease
cross sectional
atrial fibrillation
mass spectrometry
low density lipoprotein
breast cancer risk