A pediatric trial of radiation/cetuximab followed by irinotecan/cetuximab in newly diagnosed diffuse pontine gliomas and high-grade astrocytomas: A Pediatric Oncology Experimental Therapeutics Investigators' Consortium study.

Margaret E MacyMark W KieranSusan N ChiKenneth J CohenTobey J MacDonaldAmy A SmithMichael M EtzlMichele C KueiAndrew M DonsonLia GoreJennifer DiRenzoTanya M TrippettIrina OstrovnayaAru NarendranNicholas K ForemanIra J Dunkel

Published in: Pediatric blood & cancer (2017)

The trial did not meet the predetermined endpoint to deem this regimen successful for HGA. While the trial met the predetermined endpoint for DIPG, overall survival was not markedly improved from historical controls, therefore does not merit further study in this population.

Keyphrases

high grade
study protocol
phase iii
clinical trial
newly diagnosed
low grade
phase ii
palliative care
randomized controlled trial
small molecule
squamous cell carcinoma
open label
locally advanced
rectal cancer