Cell death and inflammation during obesity: "Know my methods, WAT(son)".
Ximena HildebrandtMohamed IbrahimNieves PeltzerPublished in: Cell death and differentiation (2022)
Obesity is a state of low-grade chronic inflammation that causes multiple metabolic diseases. During obesity, signalling via cytokines of the TNF family mediate cell death and inflammation within the adipose tissue, eventually resulting in lipid spill-over, glucotoxicity and insulin resistance. These events ultimately lead to ectopic lipid deposition, glucose intolerance and other metabolic complications with life-threatening consequences. Here we review the literature on how inflammatory responses affect metabolic processes such as energy homeostasis and insulin signalling. This review mainly focuses on the role of cell death in the adipose tissue as a key player in metabolic inflammation.
Keyphrases
- insulin resistance
- cell death
- adipose tissue
- oxidative stress
- type diabetes
- low grade
- metabolic syndrome
- high fat diet induced
- high fat diet
- weight loss
- skeletal muscle
- polycystic ovary syndrome
- cell cycle arrest
- weight gain
- systematic review
- high grade
- glycemic control
- fatty acid
- cell proliferation
- risk factors
- blood glucose