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VATICAN (Ventilator-Associated Tracheobronchitis Initiative to Conduct Antibiotic Evaluation): protocol for a multicenter randomized open-label trial of watchful waiting versus antimicrobial therapy for ventilator-associated tracheobronchitis.

null nullBruno Martins TomaziniBruno Adler Maccagnan Pinheiro BesenCamila DietrichAna Paula Rossi GandaraDebora Patrícia SilvaCarla Cristina Gomes PinheiroMariane Nascimento LuzRenata Rodrigues de MattosLuiz Fernando Lima ReisRoberta Muriel Longo RoepkeCarlos Sérgio Luna Gomes DuarteAntonio Paulo Nassar JuniorViviane Cordeiro VeigaBeatriz ArnsGiovanna Marssola NascimentoAdriano Pereira PagliaAlexandre Biasi CavalcantiFlávia Ribeiro MachadoLuciano César Pontes de Azevedo
Published in: Critical care science (2024)
The VATICAN trial will follow all national and international ethical standards. We aim to publish the trial in a high-visibility general journal and present it at critical care and infectious disease conferences for dissemination. These results will likely be immediately applicable to the bedside upon trial completion and will provide information with a low risk of bias for guideline development.
Keyphrases
  • phase iii
  • open label
  • phase ii
  • study protocol
  • clinical trial
  • double blind
  • placebo controlled
  • randomized controlled trial
  • infectious diseases
  • staphylococcus aureus
  • phase ii study
  • radiation therapy