Rescue of impaired blood-brain barrier in tuberous sclerosis complex patient derived neurovascular unit.

Jacquelyn A BrownShannon L FaleyMonika JudgePatricia WardRebecca A IhrieRobert CarsonLaura ArmstrongMustafa SahinJohn P WikswoKevin C EssM Diana Neely

Published in: Journal of neurodevelopmental disorders (2024)

Our results demonstrate the utility of microphysiological systems to study human neurological disorders and advance our knowledge of cell lineages contributing to TSC pathogenesis and informs future therapeutics.

Keyphrases

blood brain barrier
cerebral ischemia
endothelial cells
healthcare
single cell
cell therapy
small molecule
current status
pluripotent stem cells
bone marrow
subarachnoid hemorrhage