Extracellular and intracellular functions of coiled-coil domain containing 3.
Sara OmariHyemin LeeJieqiong WangShelya X ZengHua LuPublished in: Journal of molecular cell biology (2023)
Coiled-coil domain containing 3 (CCDC3, also called favine) is a highly conserved protein initially identified as a protein secreted from adipocytes and endothelial cells (ECs) in the vascular system with endocrine-like functions. Recently, CCDC3 was also found to function as a nuclear tumor suppressor in breast cancers (BrCs). Although it is still understudied, CCDC3, since its discovery, has been shown to play multiple roles in lipid metabolism, fatty liver, abdominal obesity, anti-inflammation, atherosclerosis, and cancer. This essay is thus composed to offer an overview of these extracellular endocrine-like and intracellular (nuclear) functions of CCDC3. We will also discuss the possible underlying cellular and molecular mechanisms of CCDC3, their implications for clinical translation, and the remaining puzzles about this special molecule.
Keyphrases
- endothelial cells
- metabolic syndrome
- type diabetes
- protein protein
- oxidative stress
- insulin resistance
- amino acid
- cardiovascular disease
- weight loss
- transcription factor
- papillary thyroid
- reactive oxygen species
- high fat diet induced
- weight gain
- fatty acid
- high throughput
- vascular endothelial growth factor
- physical activity
- skeletal muscle