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Positive Outcome Bias in the Influential Otolaryngology Clinical Trial Literature.

Hong-Ho YangMatthew TsaiLaith MukdadMaie St John
Published in: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery (2023)
The otolaryngology clinical trial literature has been heavily dominated by positive findings. CTPs were more frequently cited and published even with a lower level of evidence compared to CTNs. This bias may influence the objectivity of evidence used to guide clinical practice and warrants attention when reviewing findings and changing practices.
Keyphrases
  • clinical trial
  • clinical practice
  • systematic review
  • phase ii
  • open label
  • healthcare
  • study protocol
  • double blind
  • working memory
  • randomized controlled trial
  • placebo controlled