Estrogen Receptor Mutations as Novel Targets for Immunotherapy in Metastatic Estrogen Receptor-positive Breast Cancer.
Jonathan GoldbergNa QiaoJennifer L GuerrieroBrett GrossYagiz MeneksedagYoshimi F LuAnne V PhilipsTasnim RahmanFunda Meric-BernstamJason RoszikKen ChenRinath M JeselsohnSara M TolaneyGeorge E PeoplesGheath Al-AtrashElizabeth A MittendorfPublished in: Cancer research communications (2024)
Estrogen receptor (ESR1) mutations have emerged as a key factor in endocrine therapy resistance. We identified and validated five novel, immunogenic ESR1-derived peptides that could be targeted through vaccine-based immunotherapy.