Interaction of Mitochondrial Polygenic Score and Lifestyle Factors in LRRK2 p.Gly2019Ser Parkinsonism.
Theresa LüthCarolin GabbertSebastian KochInke R KönigAmke CaliebeBjörn-Hergen LaabsFaycel HentatiSamia Ben SassiRim AmouriMalte SpielmannChristine KleinAnne GrünewaldMatthew J FarrerJoanne TrinhPublished in: Movement disorders : official journal of the Movement Disorder Society (2023)
The MGS was more strongly associated with earlier AAO in LRRK2-PD compared with iPD. Caffeinated soda consumption or tobacco use interacted with MGS to predict AAO. Our study suggests gene-environment interactions as modifiers of AAO in LRRK2-PD. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.