Allopurinol use during pediatric acute lymphoblastic leukemia maintenance therapy safely corrects skewed 6-mercaptopurine metabolism, improving inadequate myelosuppression and reducing gastrointestinal toxicity.
Gordon CohenStacy L CooperEdward Allan SisonColleen AnnesleyMariam BhuiyanPatrick BrownPublished in: Pediatric blood & cancer (2020)
Allopurinol during ALL maintenance chemotherapy is a safe, feasible, and effective intervention for those who have altered metabolism of 6MP causing toxicity or inadequate myelosuppression.