Opposing Roles of SPOP Mutations in Human Prostate and Endometrial Cancers.
Ludimila CavalcanteSachin Kumar DeshmukhJennifer R RibeiroBenedito A CarneiroDon S DizonKartik AngaraTyler MattoxSharon WuJoanne XiuPhillip WalkerMatthew J OberleyChadi NabhanHaojie HuangEmmanuel S AntonarakisPublished in: JCO precision oncology (2023)
mutations drive opposing molecular and immune landscapes in prostate and endometrial cancers-suggesting a loss-of-function mechanism in prostate cancer and gain-of-function mechanism in endometrial cancer-and provide a rationale for tailored therapeutic approaches.