Intent-to-treat analysis of cluster randomized trials when clusters report unidentifiable outcome proportions.

Stacia M DeSantisRuosha LiYefei ZhangXueying WangSally W VernonBarbara C TilleyGary Koch

Published in: Clinical trials (London, England) (2020)

The article demonstrates that an innovative bivariate generalized estimating equations framework allows one to implement an intent-to-treat analysis to obtain risk ratios or odds ratios, for a variety of cluster randomized designs.

Keyphrases

double blind
open label
phase iii
placebo controlled
clinical trial
randomized controlled trial
study protocol