Massively parallel combination screen reveals small molecule sensitization of antibiotic-resistant Gram-negative ESKAPE pathogens.
Megan W TseMeilin ZhuBenjamin PetersEfrat HamamiJulie ChenKathleen P DavisSamuel NitzJuliane WellerThulasi WarrierDiana K HuntYoelkys MoralesTomohiko KawateJeffrey L GaulinJon H ComeJuan Hernandez-BirdWenwen HuoIsabelle NeisewanderLaura L KiesslingDeborah T HungJoan MecsasBree B AldridgeRalph R IsbergPaul C BlaineyPublished in: bioRxiv : the preprint server for biology (2024)
. We generated P2-56-3, a more potent derivative of P2-56, and found that it likely potentiates rifampin by compromising the outer membrane integrity. Our study demonstrates a high-throughput strategy for identifying antibiotic potentiators against multidrug-resistant bacteria.