Obesity in Heart Failure with Preserved Ejection Fraction: Insights from the REDUCE LAP-HF II Trial.
Sheldon E LitwinJan KomtebeddeTim SeidlerBarry A BorlaugSebastian WinklerScott D SolomonJean-Christophe EicherSula MazimbaRami KhawashAaron L SverdlovScott L HummelHeiko BuggerFlorian BoennerElke HoendermisMaja CikesCatherine DemersGuillherme SilvaVanessa van EmpelRandall StarlingMartin PenickaDonald E CutlipMartin B LeonDalane W KitzmanDirk J van VeldhuisenSanjiv J Shahnull nullPublished in: European journal of heart failure (2023)
Increasing severity of obesity was associated with greater cardiac remodeling, higher right and left ventricular filling pressures, higher cardiac output and increased subsequent HF events. Despite significant obesity, many HFpEF patients have preserved right heart and pulmonary vascular function and thus, may be appropriate candidates for atrial shunt therapy. This article is protected by copyright. All rights reserved.
Keyphrases
- left ventricular
- insulin resistance
- weight loss
- metabolic syndrome
- high fat diet induced
- type diabetes
- weight gain
- end stage renal disease
- heart failure
- ejection fraction
- newly diagnosed
- atrial fibrillation
- chronic kidney disease
- clinical trial
- pulmonary hypertension
- left atrial
- acute myocardial infarction
- hypertrophic cardiomyopathy
- stem cells
- aortic stenosis
- prognostic factors
- cardiac resynchronization therapy
- peritoneal dialysis
- adipose tissue
- randomized controlled trial
- pulmonary artery
- mesenchymal stem cells
- bone marrow
- coronary artery disease
- pulmonary arterial hypertension
- phase iii
- open label
- physical activity
- patient reported