MicroRNA 29 modulates β-cell mitochondrial metabolism and insulin secretion via underlying miR-29-OXPHOS complex pathways.
Elaine CowanJiangming SunAlexander HamiltonS RuhrmannAlexandros KaragiannopoulosEfraim WestholmJones K OforiCheng LuanEnming ZhangHindrik MulderLena EliassonPublished in: Acta physiologica (Oxford, England) (2024)
We conclude miR-29 is a key miRNA in regulating β-cell mitochondrial metabolism and insulin secretion via underlying miR-29-OXPHOS complex pathways. Furthermore, we infer reduced miR-29 expression compensatorily enhances insulin secretion under glucotoxicity.