Antifibrotic effect of lung-resident progenitor cells with high aldehyde dehydrogenase activity.

Hiroshi TakahashiTaku NakashimaTakeshi MasudaMasashi NambaShinjiro SakamotoKakuhiro YamaguchiYasushi HorimasuShintaro MiyamotoHiroshi IwamotoKazunori FujitakaHironobu HamadaNoboru Hattori

Published in: Stem cell research & therapy (2021)

Our results strongly suggest that the lung expression of ALDH and lung-resident CD45-/ALDHbr cells are involved in pulmonary fibrosis. The current study signified the possibility that CD45-/ALDHbr cells could find application as novel and useful cell therapy tools in pulmonary fibrosis treatment.

Keyphrases

pulmonary fibrosis
cell therapy
induced apoptosis
cell cycle arrest
patient safety
poor prognosis
stem cells
quality improvement
signaling pathway
mesenchymal stem cells
long non coding rna
replacement therapy
emergency medicine