Patent ductus arteriosus (also non-hemodynamically significant) correlates with poor outcomes in very low birth weight infants. A multicenter cohort study.
Elena ChesiKatia RossiGina AncoraCecilia BaraldiMara CorradiFrancesco Di DioGiorgia Di FazzioSilvia GallettiGiovanna MescoliIrene PapaAgostina SolinasLuca BragliaAntonella Di CaprioRiccardo Cuoghi CostantiniFrancesca MiselliAlberto BerardiGiancarlo GarganoPublished in: PloS one (2024)
The increased risk of mortality in neonates with non-hsPDA underscores the potential inadequacy of criteria for defining hsPDA within the first 3 postnatal days (as they may be adversely affected by other clinically severe factors, i.e. persistent pulmonary hypertension and mechanical ventilation). Parameters such as length, diameter, and morphology may serve as more suitable ultrasound indicators during this period, to be combined with clinical data for individualized management. Additionally, BPD, IVH (grade ≥ 3) and ROP (grade ≥ 3) are associated with hsPDA. The existence of an optimal timeframe for closing PDA to minimize these adverse neonatal outcomes remains uncertain.
Keyphrases
- drug induced
- low birth weight
- preterm infants
- mechanical ventilation
- pulmonary hypertension
- human milk
- preterm birth
- acute respiratory distress syndrome
- intensive care unit
- magnetic resonance imaging
- cardiovascular events
- pulmonary arterial hypertension
- respiratory failure
- emergency department
- computed tomography
- electronic health record
- cardiovascular disease
- risk factors
- cross sectional
- coronary artery
- risk assessment
- artificial intelligence
- big data
- early onset
- weight loss