Exploring with [18F]UCB-H the in vivo Variations in SV2A Expression through the Kainic Acid Rat Model of Temporal Lobe Epilepsy.
Maria Elisa SerranoMohamed Ali BahriGuillaume BeckerAlain SeretCharlotte GermonpréChristian LemaireFabrice GiacomelliFrédéric MievisAndré LuxenEric SalmonBernard RogisterRobrecht RaedtAlain PlenevauxPublished in: Molecular imaging and biology (2021)
Even if further studies in humans are required, the ability to detect a progressive decrease in SV2A expression during the development of temporal lobe epilepsy supports the use of [18F]UCB-H as a useful tool to differentiate, in vivo, between healthy and epileptic animals along with the development of the epileptic disease.