SP1-activated USP27X-AS1 promotes hepatocellular carcinoma progression via USP7-mediated AKT stabilisation.

Chen SuHaoquan ZhangJie MoZhibin LiaoBixiang ZhangPeng Zhu

Published in: Clinical and translational medicine (2024)

Novel oncogenic lncRNA USP27X-AS1 promoted HCC progression via recruiting USP7 to deubiquitinate AKT. SP1 transcriptionally activated USP27X-AS1 expression. These findings shed light on HCC and pointed to USP27X-AS1 as a potential predictive biomarker and treatment target for the malignancy.

Keyphrases

signaling pathway
cell proliferation
poor prognosis
long non coding rna
risk assessment
climate change
binding protein