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A mouse model featuring tissue-specific deletion of p53 and Brca1 gives rise to mammary tumors with genomic and transcriptomic similarities to human basal-like breast cancer.

Daniel P HollernCristina M ContrerasStephanie Dance-BarnesGrace O SilvaAdam D PfefferleJessie XiongDavid B DarrJerry UsaryKevin R MottCharles M Perou
Published in: Breast cancer research and treatment (2018)
These findings demonstrate that this model is a valuable preclinical resource for the study of human basal-like breast cancer.
Keyphrases
  • endothelial cells
  • mouse model
  • induced pluripotent stem cells
  • pluripotent stem cells
  • single cell
  • dna methylation
  • genome wide
  • cell therapy