A mouse model featuring tissue-specific deletion of p53 and Brca1 gives rise to mammary tumors with genomic and transcriptomic similarities to human basal-like breast cancer.
Daniel P HollernCristina M ContrerasStephanie Dance-BarnesGrace O SilvaAdam D PfefferleJessie XiongDavid B DarrJerry UsaryKevin R MottCharles M PerouPublished in: Breast cancer research and treatment (2018)
These findings demonstrate that this model is a valuable preclinical resource for the study of human basal-like breast cancer.