Diverse Immune Effects of Bovine Colostrum and Benefits in Human Health and Disease.
Subrata GhoshMarietta IacucciPublished in: Nutrients (2021)
The health benefits of bovine colostrum have extensively been studied, including immune effects mediated by immunoglobulins, lactoferrin, and casein, as well as by certain growth factors. Some of these effects are not directly related to the absorption of proteins from the intestinal tract. The ingestion of BC can modulate the function of subsets of lymphocytes, macrophages, and dendritic cells and increase regulatory cytokines such as interleukin 10. In this review, we predominantly focused on evidence from human studies on benefits in health and disease. This review highlights that clear evidence of the prevention of infectious diseases in pre-term infants such as necrotizing enterocolitis, neonatal sepsis or prevention of cancer metastasis is lacking. This is clearly an area where translational science has to be strengthened, taking the considerable evidence from numerous ex vivo studies on cells and tissues and from animal interventions. The review focuses predominantly on human data.
Keyphrases
- human health
- public health
- dendritic cells
- endothelial cells
- risk assessment
- infectious diseases
- healthcare
- mental health
- gene expression
- induced apoptosis
- induced pluripotent stem cells
- peripheral blood
- physical activity
- immune response
- pluripotent stem cells
- human milk
- health information
- cell cycle arrest
- case control
- electronic health record
- low birth weight
- health promotion
- drug induced