Small non-coding RNA sequencing reveals global dysregulation of piwi-interacting RNA (piRNA) expression in gonadal malignant germ cell tumours.

Sean LaidlawLuz Alonso-CrisostomoShivani BaileyHarpreet K SainiAttila MolnárJames C NicholsonAnton J EnrightCinzia G ScarpiniRaheleh RahbariNicholas ColemanMatthew Jonathan Murraynull null

Published in: Andrology (2022)

This study confirms previous miRNA observations, giving credence to our novel demonstration of global piRNA dysregulation in gonadal malignant GCTs, through both ME and non-ME-associated pathways, which likely contributes to GCT pathogenesis.

Keyphrases

germ cell
poor prognosis
single cell
long non coding rna
protein kinase