Circulating sex hormone binding globulin levels are modified with intensive lifestyle intervention, but their changes did not independently predict diabetes risk in the Diabetes Prevention Program.

Vanita R ArodaCostas A ChristophiSharon L EdelsteinLeigh PerreaultCatherine KimSherita Hill GoldenEdward HortonKieren J Mathernull null

Published in: BMJ open diabetes research & care (2021)

Lifestyle intervention may be associated with favorable changes in circulating SHBG, which is largely due to changes in adiposity. Changes in circulating SHBG do not independently predict reductions in diabetes incidence.

Keyphrases

cardiovascular disease
type diabetes
glycemic control
randomized controlled trial
metabolic syndrome
weight loss
physical activity
risk factors
skeletal muscle
body mass index
binding protein
weight gain