Chromatin accessibility landscapes of immune cells in rheumatoid arthritis nominate monocytes in disease pathogenesis.
Dandan ZongBeibei HuangYoung LiYichen LuNan XiangChuang GuoQian LiuQing ShaPengcheng DuQiaoni YuWen ZhangPengfei CaiYanping SunJinhui TaoXiaomei LiShanbao CaiKun QuPublished in: BMC biology (2021)
Together, our study revealed a CRP-induced pathogenic chromatin dysregulation signature in monocytes from RA patients and predicted the responsible signalling pathway as potential therapeutic targets for the disease.
Keyphrases
- rheumatoid arthritis
- end stage renal disease
- gene expression
- dna damage
- newly diagnosed
- disease activity
- transcription factor
- chronic kidney disease
- ejection fraction
- genome wide
- dendritic cells
- peripheral blood
- ankylosing spondylitis
- prognostic factors
- interstitial lung disease
- risk assessment
- high glucose
- diabetic rats
- systemic lupus erythematosus
- immune response
- idiopathic pulmonary fibrosis
- drug induced