Effects of Recombinant Human Growth Hormone on the Onset of Puberty, Leydig Cell Differentiation, Spermatogenesis and Hypothalamic KISS1 Expression in Immature Male Rats.

Kyoung Huh Won Heun Nah Yang Xu Mi-Jung Park Myung Chan Gye

Published in: The world journal of men's health (2020)

Prepubertal rhGH-treatment in male rats may induce early onset of puberty, sexual maturation, elevation of testosterone, and spermatogenesis, and accompanies downregulation of hypothalamic KISS1.

Keyphrases

early onset
recombinant human
growth hormone
late onset
poor prognosis
replacement therapy
cell proliferation
mental health
binding protein
signaling pathway
combination therapy