COVID-19 and vertical transmission: assessing the expression of ACE2/TMPRSS2 in the human fetus and placenta to assess the risk of SARS-CoV-2 infection.

Max Arran Beesley Joseph Rutherford DavidsonF PanarielloSoichi Shibuya Dominic Scaglioni Brendan C JonesK MaksymO OgunbiyiN J SebireD CacchiarelliAnna Louise David Paolo de Coppi Mattia Francesco Maria Gerli

Published in: BJOG : an international journal of obstetrics and gynaecology (2021)

This work provides detailed mechanistic insight into the relative protection & vulnerabilities of the fetus & placenta to SARS-CoV-2 infection by scRNAseq & protein expression analysis for ACE2 & TMPRSS2. The findings help to explain the low rate of vertical transmission.

Keyphrases

respiratory syndrome coronavirus
angiotensin converting enzyme
coronavirus disease
sars cov
angiotensin ii
endothelial cells
poor prognosis
binding protein
induced pluripotent stem cells
protein protein
amino acid
long non coding rna
genome wide identification