HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling.

Michela TerriPilar SandovalGiulio BontempiClaudia MontaldoHenar Tomero-SanzValeria de TurrisFlavia TrionfettiLucía Pascual-AntónIrene Clares-PedreroCecilia BattistelliSergio ValenteClemens ZwergelAntonello MaiLaura RosanòMiguel Ángel Del PozoMiguel Sánchez-ÁlvarezCarlos CabañasMarco TripodiManuel López-CabreraRaffaele Strippoli

Published in: Journal of experimental & clinical cancer research : CR (2024)

Our study unveils a direct impact of HDAC-1/2 in the regulation of MC/EOC adhesion and highlights the regulation of MC plasticity by epigenetic inhibition as a potential target for therapeutic intervention in EOC peritoneal metastasis.

Keyphrases

extracellular matrix
histone deacetylase
cell migration
randomized controlled trial
dna methylation
gene expression
cell adhesion
protein protein
climate change
human health
amino acid