Epigenetic aging of human hematopoietic cells is not accelerated upon transplantation into mice.

Joana FrobelSusann RahmigJulia FranzenClaudia WaskowWolfgang Wagner

Published in: Clinical epigenetics (2018)

Epigenetic changes of human hematopoietic development are recapitulated in the murine transplantation model, whereas epigenetic aging is not accelerated by the faster aging environment and seems to occur in the cell intrinsically.

Keyphrases

endothelial cells
dna methylation
gene expression
cell therapy
bone marrow
induced pluripotent stem cells
induced apoptosis
pluripotent stem cells
single cell
type diabetes
stem cells
mesenchymal stem cells
adipose tissue
cell death
endoplasmic reticulum stress
insulin resistance