Application of genomics to identify therapeutic targets in recurrent pediatric papillary thyroid carcinoma.
Rebecca RonsleyShahrad Rod RassekhYaoqing ShenAnna F LeeColleen JantzenJessica HalparinCatherine AlbertDouglas S HawkinsShazhan AmedRalph RothsteinAndrew J MungallDavid DixGeoffrey BlairHelen Ruth NadelSteven J M JonesJanessa LaskinMarco A MarraRebecca J DeyellPublished in: Cold Spring Harbor molecular case studies (2018)
Children with papillary thyroid carcinoma (PTC) may relapse despite response to radioactive iodine (RAI). Two children with multiply relapsed PTC underwent whole-genome and transcriptome sequencing. A TPM3-NTRK1 fusion was identified in one tumor, with outlier NTRK1 expression compared to the TCGA thyroid cancer compendium and to Illumina BodyMap normal thyroid. This patient demonstrated resolution of multiple pulmonary nodules without toxicity on oral TRK inhibitor therapy. A RET fusion was identified in the second tumor, another potentially actionable finding. Identification of oncogenic drivers in recurrent pediatric PTC may facilitate targeted therapy while avoiding repeated RAI.
Keyphrases
- single cell
- lymph node
- lymph node metastasis
- young adults
- poor prognosis
- acute lymphoblastic leukemia
- rna seq
- acute myeloid leukemia
- oxidative stress
- pulmonary hypertension
- gene expression
- case report
- squamous cell carcinoma
- genome wide
- diffuse large b cell lymphoma
- magnetic resonance imaging
- hodgkin lymphoma
- free survival
- computed tomography
- binding protein
- magnetic resonance
- dual energy