Cyproheptadine, an epigenetic modifier, exhibits anti-tumor activity by reversing the epigenetic silencing of IRF6 in urothelial carcinoma.

Yeong-Chin JouGuan-Ling LinHon-Yi LinWan-Hong HuangYu-Ming ChuangRu-Inn LinPie-Che ChenShu-Fen WuCheng-Huang ShenMichael Wing-Yan Chan

Published in: Cancer cell international (2021)

In conclusion, our results suggested that CPH may be an epigenetic modifier, modulating the expression of the potential tumor suppressor IRF6, in inhibiting tumor growth in UC.

Keyphrases

dna methylation
gene expression
signaling pathway
dendritic cells
poor prognosis
immune response
binding protein
climate change
risk assessment