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Cyproheptadine, an epigenetic modifier, exhibits anti-tumor activity by reversing the epigenetic silencing of IRF6 in urothelial carcinoma.

Yeong-Chin JouGuan-Ling LinHon-Yi LinWan-Hong HuangYu-Ming ChuangRu-Inn LinPie-Che ChenShu-Fen WuCheng-Huang ShenMichael Wing-Yan Chan
Published in: Cancer cell international (2021)
In conclusion, our results suggested that CPH may be an epigenetic modifier, modulating the expression of the potential tumor suppressor IRF6, in inhibiting tumor growth in UC.
Keyphrases
  • dna methylation
  • gene expression
  • signaling pathway
  • dendritic cells
  • poor prognosis
  • immune response
  • binding protein
  • climate change
  • risk assessment