TCOF1 upregulation in triple-negative breast cancer promotes stemness and tumour growth and correlates with poor prognosis.

Jianyang HuYuni LaiHao HuangSaravanan RamakrishnanYilin PanVictor W S MaWah CheukGrace Y K SoQingling HeC Geoffrey LauLiang ZhangWilliam Chi Shing ChoKui Ming ChanXin Wang Y Rebecca Chin

Published in: British journal of cancer (2021)

TCOF1 depletion potently attenuates the growth and stemness of basal-like TNBC. Expression of TCOF1 may serve as a TNBC prognostic marker and a therapeutic target.

Keyphrases

poor prognosis
long non coding rna
stem cells
epithelial mesenchymal transition
signaling pathway
cell proliferation
binding protein