CYP2C9 gene polymorphisms influence on antihypertensive effectiveness and hypouricemic effect of losartan among patients with arterial hypertension: an observational study.
Irina I SinitsinaAlexey V BoyarkoIlyas I TemirbulatovDmitry Alekseevich SychevKristina Anatolyevna AkmalovaZhannet Alimovna SozaevaElena A GrishinaKarin Badavievich MirzaevAnastasiia V AsoskovaVladimir P FisenkoPublished in: Drug metabolism and personalized therapy (2022)
) reduced the hypotensive effect of losartan according to ABPM and don't affect uric acid level in plasma and E-3174/losartan in urine.