Mutated NPM1 in combination with overexpression of Meis1 or Hoxa9 is not sufficient to induce acute myeloid leukemia.

Hanna Grauers WiktorinTina NilssonAnn JanssonLars PalmqvistAnna Martner

Published in: Experimental hematology & oncology (2016)

There was no synergy between NPMc(+) and Meis1 or Hoxa9 in causing leukemogenic transformation of murine bone marrow cells, or in inducing AML in a transplantation model. Hence, overexpression of Meis1 or Hoxa9 in combination with NPMc(+) expression was not sufficient to generate an NPMc(+) AML mouse model.

Keyphrases

acute myeloid leukemia
long non coding rna
bone marrow
poor prognosis
mouse model
long noncoding rna
allogeneic hematopoietic stem cell transplantation
induced apoptosis
cell proliferation
transcription factor
cell cycle arrest
mesenchymal stem cells
oxidative stress
cell therapy
cell death
pi k akt