Collagen Remodeling and Fatty Acid Regulation Biomarkers in Understanding the Molecular Pathogenesis of Atrial Fibrillation.

Ameer OdehGabriel D DunganAmir DarkiDebra Moorman Hoppensteadt Fakiha Siddiqui Bulent Kantarcioglu Jawed FareedMushabbar A Syed

Published in: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis (2022)

The elevation of collagen remodeling biomarkers suggests an upregulation of these biomarkers and their potential role in AF, which may contribute to atrial fibrosis. L-FABP and NEFAs were elevated in AF patients. The correlations between the collagen remodeling and fatty acid dysregulation biomarkers may be due to their involvement in structural remodeling of the atria.

Keyphrases

atrial fibrillation
fatty acid
catheter ablation
left atrial
heart failure
end stage renal disease
left atrial appendage
oral anticoagulants
cell proliferation
prognostic factors
signaling pathway
binding protein
patient reported outcomes